primary hepatic amyloidosis with severe cholestasis: a case report

نویسندگان

marziye ghalamkari internal medicine resident at imam khomeini hospital,tums

mahdi khatuni researcher, department of internal medicine, imam khomeini hospital,tehran university of medical sciences, tehran, iran

mohammad taher fellowship of gastroenterology, imam khomeini hospital,tehran university of medical sciences, tehran, iran

mahmood khaniki assistant professor, department of pathology, imam khomeini hospital,tehran university of medical sciences, tehran, iran

چکیده

despite the fact that hepatic involvement is frequently seen in systemic primary amyloidosis, major hepatic symptoms as primary manifestation and severe impaired liver function are rare. herein, we report a 38-year-old woman with primary hepatic amyloidosis, and severe  portal hypertension . the patient had ascites and markedly elevated alkaline phosphatase level at presentation. she had a rapid downhill course resulting in death. in case of an unexplained intrahepatic cholestasis or portal hypertension the possibility of amyloidosis should be considered and a  congo red staining should be performed.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acase report of primary amyloidosis with prominent hepatic involvement

primary amyloidosis is a rare disrder wihich is diagnosed by extracellular deposition of proteinaceous material in different organs.in this report,a case of this disease with prominent hepatic involvement is presented.the case is a 63 years old male refered with abdominal enlargement,weight loss,generalized pruritus,anorexia and vague abdominal pain started from six months ago.on physical exami...

متن کامل

Primary Localized Vesical Amyloidosis Mimicking Bladder Carcinoma: A Case Report

Amyloidosis of urinary bladder is a rare condition and may be primary or secondary in nature. A case of primary localized vesical amyloidosis (VA) in a 40-yr-old man is described confused with neoplasm by cystoscopic, urographic. Surgical specimens obtained by transurethral resection (TUR) were diagnostic and histologically revealed amyloid deposits in sub-epithelial stroma with chronic inflamm...

متن کامل

A case of primary systemic amyloidosis with nail dystrophy

We hereby report a 79-year-old Iranian man presenting with nail dystrophy and subsequent development of purpuric and ecchymotic plaques, hemorrhagic bullae, and infiltrated papules on the head, neck and trunk. Histological examination of the gingiva, bone marrow aspiration, and biopsy confirmed the diagnosis of primary systemic amyloidosis. In this case, nail dystrophy was the presenting sign o...

متن کامل

A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis

The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to amyloidosis. Our patient had the primal symptoms of hyperbili...

متن کامل

Cholestasis with hepatic fibrosis secondary to sarcoidosis--a case report.

Sarcoidosis is a chronic granulomatous disease of unknown etiology occurring world wide. The problem of diagnosis of sarcoidosis in a country like Pakistan is two fold: lack of awareness of its existence and difficulty in differentiating it from the highly prevalent tuberculosis with which it shares many clinical and pathological features. It can affect almost any organ. We present a case with ...

متن کامل

Severe cholestasis associated with methyltestosterone: a case report.

We report a 62-yr-old man with severe jaundice and weight loss attributed to methyltestosterone administration. This case is unusual both in the severity of the cholestasis as well as the associated findings that mimicked an underlying malignancy.

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
گوارش

جلد ۲۱، شماره ۱، صفحات ۷۶-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023